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An accomplished actor best known for his portrayal of Captain Benjamin “Hawkeye” Pierce in the US television series M*A*S*H, Alan Alda has taken on another impactful role in recent years: champion of science communication. Having served for 14 years as the host of Scientific American Frontiers, a public television show devoted to explaining recent advances in science and technology, in
We spend a lot of time in this business thinking about how our compounds get into cells (or why they don’t!) Cells of course have a large suite of surface proteins, channels and transporters that are responsible for moving things through the cell membrane in both directions. Sometimes our drug molecules can find themselves able to jump on board these active transport systems, but more often
“There is a great deal of ruin in a country” said Adam Smith about economics (and public order), and there’s a lot of ruin in scientific publishing as well. The traditional model for publishing research results has been taking torpedos for years now, but (contrary to earlier predictions) has not really sunk yet. Perhaps the emphasis there should be on “yet”, bec
Editor's Blog
An accomplished actor best known for his portrayal of Captain Benjamin “Hawkeye” Pierce in the US television series M*A*S*H, Alan Alda has taken on another impactful role in recent years: champion of science communication. Having served for 14 years as the host of Scientific American Frontiers, a public television show devoted to explaining recent advances in science and technology, in
Royce W. Murray, a pioneer in electrochemistry, chemically modified electrodes, self-assembled monolayers, and ionic liquids, died on 6 July at age 85. Much of how we think about modifying surfaces and measuring changes induced by those modifications comes from Murray’s lab. Murray’s scientific accomplishments have been enumerated elsewhere, but those who knew him will best remember hi
Ten years ago, an editorial in Science remarked on how little progress had been made on improving the postdoctoral experience since a landmark report in 2000 detailed the variability of such positions. Postdoctoral scholars (postdocs) are hardly better off in 2022; however, postdoctoral fellowship programs can serve as the nuclei for changes that have long been recognized as necessary for improvin
The past 2 years have been a period of mourning, anger, fear, and exhaustion for Asian Americans: 16% of Asian American adults were victims of hate crimes in 2021, up from 12.5% in 2020; 31% worry “all the time” or “often” about being victimized because of their race; and 36% have changed their routines over concerns about personal safety. Despite the increase in anti-Asian
Our food system is a rich, complex blend of biology and culture. From the biodiversity in forests, oceans, and farms to the living weave of long-standing traditions and emerging trends, food touches every aspect of life on Earth. This diversity hasn’t always carried through to agricultural and culinary literatures, but fortunately this is changing. Fresh perspectives are emerging in the lite
Three weeks ago, I wrote about how graduate education is still in serious need of reform and pointed to a NextGen Voices piece that we ran describing how principal investigators can be better mentors. Recently, I learned that two outstanding chemistry professors—Jen Heemstra at Emory University and Neil Garg at the University of California Los Angeles (UCLA)—had launched an initiative
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Visuals
Have you ever wondered why some research makes science news and other research doesn’t? Of course, content is king but in addition to having significant findings, strong visuals can catch the attention of the press and larger audiences. It pays to spend some time taking high-quality photos of your work and putting them somewhere a photo editor (a person like me that seeks out pictures for news sto
I remember first learning about the nuclear pore. It was in high school biology, and I was immediately struck by how it looked. Its symmetry certainly stands out: eight copies of a protein unit arranged in a ring, encircling an opening in the nuclear membrane. And they cover the nucleus like holes in a colander (if that colander was very choosy about what it let through). The next thing one notice
Working with animals is unpredictable by nature. To them, there are always more interesting things to be doing, fresh smells to sniff, and new acquaintances to make. After reading the paper on dog breed stereotypes for the 29 April issue of Science, I knew we had to have a cover with as many dogs as possible. But if you’ve ever walked by a doggy daycare, you know it’s nearly impossible to get a group of dogs to focus on one thing, let alone sit still for a portrait.
I was fascinated by the complex shape of the intricate glass sculpture. Yet it was only 4.5 millimeters tall—less than the thickness of a No. 2 pencil. But the small scale posed a big problem: Would a photograph of such a minute object work as a Science cover?
In the Pipeline
We spend a lot of time in this business thinking about how our compounds get into cells (or why they don’t!) Cells of course have a large suite of surface proteins, channels and transporters that are responsible for moving things through the cell membrane in both directions. Sometimes our drug molecules can find themselves able to jump on board these active transport systems, but more often
“There is a great deal of ruin in a country” said Adam Smith about economics (and public order), and there’s a lot of ruin in scientific publishing as well. The traditional model for publishing research results has been taking torpedos for years now, but (contrary to earlier predictions) has not really sunk yet. Perhaps the emphasis there should be on “yet”, bec
Here’s one of those reactions that looks like alchemy to most of us in the synthetic organic community, and I’m always very happy to see those. A new paper from Frances Arnold’s group at CalTech and collaborators at Binghamton illustrates some real progress in taking naked, unactivated C-H centers and functionalizing them with amine groups.
Experienced organic chemists will recog
It's been a little while since I wrote about coronaviruses per se, but some recent news (and the coverage of it, especially) prompts today's post. I'm talking about the preprint out of a Boston University research group which is being described by many as "irresponsible gain-of-function" research. I think that that's not a good characterization of it, and I think that language is likely just
Here's a rather unnerving article on using combinations of antibiotics to treat disease. There have of course been a lot of studies in this area, but they have tended to look at easier-to-measure outcomes like effects on bacterial growth. Not that that doesn't make sense! You'd think that the combinations that have the strongest effects there would also be the ones that have the best effects overa
Protein degradation has had a great deal of time, effort, and money put into it over the last few years, but it remains a pretty wild frontier. That state of affairs is either exciting or maddening, depending on what sort of investment you have riding on it, but either way it's going to be a while before things settle down. Case in point: one of the key features of this technique is enlisting a co