Advertisement
Journals
Science
- Volume 378
- Issue 6617
- 21 Oct 2022
COVER Butterfly wing patterns are mosaics of colored scales, as shown in this high-magnification image of a painted lady (Vanessa cardui) wing. A shared set of deeply conserved gene regulatory sequences are shown to control color pattern formation across species, suggesting that an ancient genetic architecture underlies wing pattern development. See pages 249 and 304.
Photo: Anyi Mazo-Vargas
Science Advances
- Volume 8
- Issue 42
- 21 Oct 2022
ONLINE COVER Emission ratios in Arabidopsis root tips visualized with a genetically encoded fluorescent biosensor. The uptake and distribution of nitrate—a major nitrogen source and one of the most limiting factors in agricultural production—is critical to plant life. Visualizing this distribution at the cellular level provides an understanding of the fundamental aspects of nitrate uptake by plant roots. To do this, Chen et al. developed NitraMeter3.0, a genetically encoded fluorescent biosensor. The tool tracks both nitrate concentrations in real time and spatiotemporal changes during the plant life cycle.
Credit: Chen et al./Science AdvancesScience Immunology
- Volume 7
- Issue 76
- Oct 2022
ONLINE COVER Mangled Myelin. This month’s cover depicts a normal myelin sheath wrapped around the axon of a neuron next to a damaged myelin sheath impairing nerve function. Autoreactive T cells specific for epitopes in myelin proteins trigger demyelination in human multiple sclerosis and mice with experimental autoimmune encephalomyelitis (EAE). Yi and Miller et al. report that chimeric antigen receptor (CAR) T cells displaying a complex of MHC class II and a peptide from myelin oligodendrocyte protein (MOG) selectively target pathogenic T cells for elimination in mouse EAE initiated by MOG immunization, thereby preventing and treating autoimmune symptoms. Using CAR T cells with different functional efficacy, the authors found that higher affinity autoreactive T cells are required for initiation of disease onset but lower affinity cells are sufficient to maintain ongoing disease.
Credit: Tim Vernon/Science SourceScience Robotics
- Volume 7
- Issue 71
- Oct 2022
ONLINE COVER Physical Connections. Morphological computing leverages the dynamics of mechanical bodies for computation with the aim to decentralize the computing load. Inspired by artificial neural networks, Lee et al. have realized a mechanical neural network that uses interconnected beams with tunable stiffness to learn mechanical behaviors. Genetic and partial pattern search algorithms were applied to the mechanical neural network. This month's cover is a photograph of the mechanical neural network in operation.
Credit: Lee et al./Science RoboticsScience Signaling
- Volume 15
- Issue 756
- 18 Oct 2022
ONLINE COVER This week, Udayasuryan et al. show that infection of normal and malignant pancreatic cells with the oral commensal microbe Fusobacterium nucleatum induces cytokine release that promotes migration and invasion by the cancer cells. In the pseudocolored scanning electron microscopy image, F. nucleatum (orange) are seen binding to and invading pancreatic cancer cells (purple).
Credit: Udayasuryan et al./Science SignalingScience Translational Medicine
- Volume 14
- Issue 667
- 19 Oct 2022
ONLINE COVER Tracking TAMs. This two-photon microscopy image shows uptake of perfluorocarbon-containing nanoparticles (PFC-NPs; red) by tumor-associated microglia and macrophages (TAMs) in a central nervous system (CNS) tumor. Vasculature is shown in yellow and tumor cells are shown in green. Increased TAM abundance in CNS tumors has been correlated to more aggressive disease; however, monitoring these cells in patients has only been achievable using invasive biopsies. Here, Croci et al. showed that CNS TAMs could be monitored by magnetic resonance imaging (MRI) for PFC-NPs enriched for the stable isotope, fluorine-19 (19F). The authors found that TAMs could be tracked longitudinally and in response to radiotherapy, highlighting the potential of 19F MRI as a monitoring strategy for patients with CNS tumors.
Credit: Davide Croci and Johanna Joyce, University of Lausanne, SwitzerlandScience Partner Journals
The Open Access journal Research, published in association with CAST, publishes innovative, wide-ranging research in life sciences, physical sciences, engineering and applied science.
The Open Access journal Plant Phenomics, published in association with NAU, publishes novel research that advances plant phenotyping and connects phenomics with other research domains.
The Open Access journal BMEF, published in association with SIBET-CAS, is a platform for the multidisciplinary community of biomedical engineering, publishing wide-ranging research in the field.
The Open Access journal BioDesign Research, published in association with NAU, publishes novel research in the interdisciplinary field of biosystems design.
The Open Access journal Advanced Devices & Instrumentation, published in association with BIACD, is a forum to promote breakthroughs and application advances at all levels of electronics and photonics.
The Open Access journal Cyborg and Bionic Systems, published in association with BIT, promotes the knowledge interchange and hybrid system codesign between living beings and robotic systems.
The Open Access journal Energy Material Advances, published in association with BIT, is an interdisciplinary platform for research in multiple fields from cutting-edge material to energy science.
The Open Access journal Space: Science & Technology, published in association with BIT, promotes the exploration and research of interdisciplinary sciences in the space field.
The Journal of Remote Sensing, an Open Access journal published in association with AIR-CAS, promotes the theory, science, and technology of remote sensing, as well as interdisciplinary research within earth and information science.
The Open Access journal Health Data Science, published in association with PKU, aims to advance the horizon of health data science through transdisciplinary learning, communication, and collaboration with health practitioners and policymakers.
The Open Access journal Ultrafast Science, published in association with XIOPM, publishes cutting-edge and emerging topics in ultrafast science with broad interest from scientific communities.
The Open Access journal Ocean-Land-Atmosphere Research (OLAR), published in association with SML-ZHUHAI, publishes technologically innovative research in marine, terrestrial, and atmospheric studies and the interactions among them.
The Open Access journal Intelligent Computing, published in affiliation with Zhejiang Lab, publishes the latest research outcomes and technological breakthroughs in intelligent computing.